Gradual Reduction in MF Effectiveness

[Jarulf]

It would be a result of a co-variance between successive random numbers that causes certain combinations of numbers to be more likely than others as time goes on.

Ehh, no, it would not change over time. It would always be more (or less) likely. Otherwise some other change would have taken place. So shifts (for runs or long playing) in ammount of failed uniques or sets can't be attributed to the prng no matter what as long as other outside parameters are the same (which they are if you kill same monster).