Why Dex-based classes are terrible.

[Lissa]

Let me tell you, as someone that is routinely playing in Act 2 Inferno (still hunting for gear to get going in Act 3), your setup won't work. You need far, far larger life on hit than 300. Likewise, mobs typically hit you for 60% to 75% of your health in one hit with 35k health.

Of course you do! Blizzard has rigged Inferno to require far bigger stats on everything, which are available only on level-60+ items. So realistically, you'd need to ramp up LoH just like everything else. If that's practical, then fine, it will continue to work, since it's not penalized in higher difficulty levels. If not, it's yet another detail in inflationary scaling that Blizzard failed to get right in the 1.03 Beta patch.

Also, only 35K HP in Inferno? I felt like 25K was barely enough to start Hell.

Did you miss that mobs are hitting you for anywhere from 20k to 30k per hit? Even at 40k health, being hit for 20k means you're going to be two shot. The difference between 35k and 40k doesn't mean squat when the mob hits you for 20k at a hit cause you're going to die if you get hit twice. Most mobs in Act 2 hit for high enough that even with having 50% phys damage reduction through resists along with 50% damage reduction from armor still takes big chunks out of you. So, you're completely missing the point, unless you have 20k LoH or 4k to 5k LoH and using Multishot and hitting 4 to 5 mobs with each MS fired, you're not going to make up that damage your taking through LoH before you die as a DH, it comes down to not even being there which means kiting like crazy and/or using Vault to get out of the way.

For LoH to really work, you have to be able to take the hits, this works for classes like Barbarian and Monk, and to a lesser extent Wizards under the right skill usage, but it doesn't work for DHs cause they don't have a strong mitigation mechanic. This is the crux of the problem.