Defensive Stance

[Mavfin]

I assume you mean that you hamstring runners when they are closer to death, not after the initial charge.  Unless you're still at a low level, I can't imagine your warrior (a defense spec'd one, especially) killing mobs in about 20 seconds each.  Or is this a "green grinding" strategy?

By the time the mid-late twenties warrior I played could bring a mob down to fleeing health, an initial hamstring would've worn off.  Of course, maybe my weapon was much crappier for the level than yours.  But I generally waited until a mob was between one-half and one-third health before using hamstring.  Fifteen seconds goes by quickly for a sword-and-board warrior.
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Depends on the mob, really. Cloth-wearers, you better do it quick and re-apply if needed, as you never know when you're going to get a big crit on them. More heavily armored, hamstring to taste. :P