Is 1.10 Hell playable?

[Zath]

Stone Skin uniques have increased physical resistance, so Amplify Damage (-100% physical resistance) and Decrepify (-50% physical resistance, among its various effects) should both be very helpful. Keep in mind that most monsters can regenerate their health completely in about 80 seconds, so you need to deal damage quickly or try to counter that regeneration. A single Skeletal Mage with a poison attack can do wonders here, although you can use your own poison skills as well.