Um or better

[whathuh]

Absolutely correct.

Even with two players in the game, she will only drop one rune (if she drops any), and it will nearly always be lower level.

Countess and Andy. Just do that run. Get the runes from countess, then some uniques/sets from Andy. Wash, rinse, repeat.
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I don't think that is correct. Even on players 8 (players 8 still has a nodrop chance) she can drop the same amount of runes, just the chances are much slimmer, and the runes should be chosen randomly from the rune drop.

And remember not to use the andy trick when killing andy, unless you can't avoid it.