Warlock's talents building

[Lissa]

Amplify Curse is a good choice by itself as it also improves your next Curse of Weakness or Agony by 50%.
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In solo PvE or 1vX, Amped CoA is of use. When you are in a group, you're better served by using a Curse other than Agony. Weakness, even Amped, is pretty much useless when you're 40+ since the damage reduction is so minor when Players and NPCs are doing non-crit hits in the 300 range (with high end Elite hand to hand trash mobs) and Bosses are doing crit hits with special powers on the order of 1.5k+. Amps only good reason is for CoEx in the end game. In PvP, instant damage is king and DoTs, while they can be helpful, usually won't be enough to win the fight.