Cosmic Sympathy

[adeyke]

You just need ilvl 26+ for Tal Rasha. That includes all act bosses from normal Mephy onward and all normal monsters from act 5 normal onward (as well as some from act 4 normal). Theoretically, it could drop from a boss/minion as early as act 2 normal (in Tal Rasha's Tomb).

So it's almost always worth picking up set amulets ;).