would a necro with breath of dying work

[Boffin]

I am interest to know if the "50% chance to cast level 20 poison nova when you kill an enemy" from the breath of the dying rune word can be increased.

I was thinking of an necromancer with poison dagger and poison explosion at level 20 giving a synergy bonus of 400% to this poison nova from the weapon. (2237 poison damge / 2 sec)
Then having the bramble rune word on the armour giving an additional 100% poision damage. (4475 poison damage / 2 sec).

Will this work? Its going to cost a bit for the rune words just to try.