Unique hunting resource help?

[vmxa]

The problem is just that the monster with the highest probability isn't necessarily the best source of an item.  You also have to factor in how many of that monster you can kill in a given time and how safe it is to do so.  As a hypothetical example, if hell Baal had a 1% chance of dropping something but normal cows had a 0.9% chance, the cows would be much, much better, even though their probability per kill is lower.
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I have seen a few mentions of Cow runs, I thought you can only get Wirt's leg to work once per level?